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Outcomes of Ayurvedic treatment in an oxygen dependent diabetic and hypertensive COVID-19 patient in the post-hospitalization period - A Case Report

##article.authors##

  • Jyoti Joshi Joshi Panchakarma Clinic, Panvel, Mumbai, India
  • Sushma NS ACARA, Amrita School of Ayurveda, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India
  • Shyamasundaran K ACARA, Amrita School of Ayurveda, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India
  • Prajeesh Nath EN ACARA, Amrita School of Ayurveda, Amrita Vishwa Vidyapeetham, Kollam, Kerala, India
  • Rammanohar Puthiyedath

DOI:

https://doi.org/10.53721/aca.19

Keywords:

COVID-19, Ayurveda, Hypoxia, SARS-CoV-2, Integrative Medicine, Case Report

Abstract

Introduction: Low oxygen saturation may persist in COVID-19 patients even after hospital discharge, requiring continued supplemental oxygen therapy at home. In this paper, we report the significant benefits of add on Ayurvedic intervention as observed in an oxygen dependent COVID-19 patient in the post hospitalization period. 

 Main symptoms and/or important clinical findings: A 75-year-old gentleman approached his Ayurvedic general practitioner with complaints of low oxygen saturation and oxygen dependency five days after being discharged from hospital, where he was treated for COVID-19 related bilateral pneumonitis and Acute Respiratory Distress Syndrome as well as Acute Renal Failure. Patient reported breathing difficulty, generalized weakness, reduced appetite and severe constipation. Pulse Oximetry readings were fluctuating between 82 and 85% even with home oxygen support. Blood pressure was found to be 150/100 mm Hg, LDH slightly raised at 463 IU/L and HbA1c at 8.7 % indicated poor control of diabetes.  The patient was administered micro-doses of a combination of Ayurvedic formulations sublingually every ten minutes for one day. This was followed by administration of IndukÄÂntaṃ Ghá¹›taṃ and SuvarṇamÄÂlinÄ« Vasanta Rasa, Oxygen saturation improved to 95% in about twelve hours. He was weaned off oxygen support on the third day of starting Ayurvedic treatment, which was three weeks earlier than prescribed at the time of discharge from the hospital. Patient is ambulant and maintaining oxygen saturation levels between 95-98%.

 Conclusion: This case report highlights the potential of a specific Ayurvedic intervention for better management of hypoxia persisting in the post hospitalization phase of patients managed with conventional medicine for COVID-19 related complications. Well-designed studies are warranted to confirm the benefits and explore the possibility of integrating such interventions appropriately with standard of care for management of COVID-19.

References

The Lancet. India's COVID-19 emergency. Lancet. 2021 May 8;397(10286):1683. doi: https://doi.org/10.1016/S0140-6736(21)01052-7

India, Brazil and the human cost of sidelining science. Nature. 2021 May;593(7857):7-8. doi: https://doi.org/10.1038/d41586-021-01166-w

Ranjan R, Sharma A, Mahendra ·, Verma K, Verma MK. Characterization of the Second

Wave of COVID-19 in India. medRxiv 2021.04.17.21255665; doi: https://doi.org/10.1101/2021.04.17.21255665

Kordzadeh-Kermani E, Khalili H, Karimzadeh I. Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19). Future Microbiol. 2020 Sep;15:1287-1305. doi: https://doi.org/10.2217/fmb-2020-0110 Epub 2020 Aug 27.

Elezkurtaj S, Greuel S, Ihlow J, Michaelis EG, Bischoff P, Kunze CA, et al. Causes ofdeath and comorbidities in hospitalized patients with COVID-19. Sci Reports.

AD;11:4263.

Puthiyedath R, Kataria S, Payyappallimana U, Mangalath P, Nampoothiri V, Sharma P, et al Ayurvedic clinical profile of COVID-19 - A preliminary report. J Ayurveda Integr Med. 2020 Jun 12:S0975-9476(20)30039-5. doi:https://doi.org/10.1016/j.jaim.2020.05.011

Ravindra Angadi, editor, Rasatarangini of Sadananda sharma: Chapter 6, Verse 207.Varanasi: Chaukhabha Surbharati Prakashan, 2015; p.98

Acaraya Yadavji Trikamji, Acarya Narayan Ram., editors. Susrutasamhita of Sushruta. Varanasi: Chaukhambha Sanskrit Sansthan. 2008. [SÅ«trasthÄÂna, 11.11], [CikitsÄÂsthÄÂna, 4.3-4]

Bhava Prakasha Nighantu. 9th ed. New Delhi: Motilal Banarsidas press; 1998. Dwivedi Vishwanatha; p. 14.

KV Krishnan Vaidyan and Anekalilil S Gopala Pillai, Sahasrayoagam, Alappuzha: Vidyarambham Publications, 2007; Ghrita prakarana. p.322

Acharya Bindu, Rasapaddhati, Siddhiprada Hindi Commentary by Siddhinandana Mishra, Second edition, Chaukhambha Orientalia Varanasi, 2005 ;p.167.

Acharya JT, editor, Carakasamhita of Caraka. Varanasi: Chaukhamba Orientalia; 2011. [CikitsÄÂsthÄÂna, 28.28], [CikitsÄÂsthÄÂna, .3-165]

Ayoubkhani D, Khunti K, Nafilyan V, Maddox T, Humberstone B, Diamond I et al. Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study. BMJ. 2021 Mar 31;372:n693. doi: https://doi.org/10.1136/bmj.n693

Borgen I, Romney MC, Redwood N, Delgado B, Alea P, George BH, et al. From Hospital to Home: An Intensive Transitional Care Management Intervention for Patients with COVID-19. Popul Health Manag. 2021 Feb;24(1):27-34. doi: https://doi.org/10.1089/pop.2020.0178 Epub 2020 Oct 14

Banerjee J, Canamar CP, Voyageur C, Tangpraphaphorn S, Lemus A, Coffey C Jr, et al. Mortality and Readmission Rates Among Patients With COVID-19 After Discharge From Acute Care Setting With Supplemental Oxygen. JAMA Netw Open. 2021 Apr 1;4(4):e213990. doi: https://doi.org/10.1001/jamanetworkopen.2021.3990

Sardesai I, Grover J, Garg M, Nanayakkara PB, Di Somma S, Paladino L, et al. Short Term Home Oxygen Therapy for COVID-19 patients: The COVID-HOT algorithm. J Family Med Prim Care. 2020 Jul 30;9(7):3209-3219. doi: https://doi.org/10.4103/jfmpc.jfmpc_1044_20

Weerahandi H, Hochman KA, Simon E, Blaum C, Chodosh J, Duan E, et al. Post-discharge health status and symptoms in patients with severe COVID-19. medRxiv [Preprint]. 2020 Aug 14:2020.08.11.20172742. doi:https://doi.org/10.1101/2020.08.11.20172742. Update in: J Gen Intern Med. 2021 Jan 14

Sarkar PK, Das Mukhopadhyay C. Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2. Int Nano Lett. 2021 Jan 6:1-7. doi: https://doi.org/10.1007/s40089-020-00323-9 . Epub ahead of print.

George SK, Rajesh R, Kumar S S, Sulekha B, Balaram P. A polyherbal ayurvedic drug--Indukantha Ghritha as an adjuvant to cancer chemotherapy via immunomodulation. Immunobiology. 2008;213(8):641-9. doi: https://doi.org/10.1016/j.imbio.2008.02.004. Epub 2008 Apr 16.

Posted

2021-05-17